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Microverse of the Host

Microverse of the Host aims to increase our functional understanding of the dynamics of human and plant microbiomes - their recruitment, composition, chemical exchange and their role in host development and fitness. Analysis and comparison of microbiomes in pre-antibiotic era humans and in critically ill patients treated with antibiotics will yield testable hypotheses. Experimental models will provide an understanding of microbiome functions that is valuable for agricultural applications, precision medicine and targeted microbial therapies.

Coordinators:
Ian Baldwin | Michael Bauer | Bernhard Hube | Georg Pohnert

Publications

2022

De Almeida GP, Lichtner P, Eckstein G, Brinkschmidt T, Chu CF, Sun S, Reinhard J, Maedler SC, Kloeppel M, Verbeek M, Zielinski CE (2022) Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential. Science Immunology, doi: 10.1126/sciimmunol.abe2634.
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Westman J, Plumb J, Licht A, Yang M, Allert S, Naglik JR, Hube B, Grinstein S, Maxson ME (2022) Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion. Cell Reports, doi: 10.1016/j.celrep.2021.110187.
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2021

Wu Y, Zeng Z, Guo Y, Song L, Weatherhead JE, Huang X, Zeng Y, Bimler L, Chang CY, Knight JM, Valladolid C, Sun H, Cruz MA, Hube B, Naglik JR, Luong AU, Kheradmand F, Corry DB (2021) Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization. Immunity, doi: 10.1016/j.immuni.2021.08.009.
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Marfil-Sánchez A, Zhang L, Alonso-Pernas P, Mirhakkak M, Mueller M, Seelbinder B, Ni Y, Santhanam R, Busch A, Beemelmanns C, Ermolaeva M, Bauer M, Panagiotou G (2021) An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness. Gut Microbes, doi: 10.1080/19490976.2021.1993598.
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Jentho E, Ruiz-Moreno C, Novakovic B, Kourtzelis I, Megchelenbrink W, Martins R, Chavakis T, Soares MP, Kalafati L, Guerra J, Roestel F, Bohm P, Godmann M, Grinenko T, Eugster A, Beretta M, Joosten L, Netea M, Bauer M, Stunnberg H, Weis S (2021) Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme. PNAS, doi: 10.1073/pnas.2102698118.
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Venkat K, Hoyos M, Haycocks J, Cassidy L, Engelmann B, Rolle-Kampczyk U, von Bergen M, Tholey A, Grainger D, Papenfort K (2021) A dual-function RNA balances carbon uptake and central metabolism in Vibrio cholerae. EMBO J, doi: 10.15252/embj.2021108542.
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Press AT, Babic P, Hoffmann B, Müller T, Foo W, Hauswald W, Benecke J, Beretta M, Cseresnyés Z, Hoeppener S, Nischang I, Coldewey SM, Gräler MH, Bauer R, Gonnert F, Gaßler N, Wetzker R, Figge MT, Schubert US, Bauer M (2021) Targeted delivery of a phosphoinositide 3-kinase y inhibitor to restore organ function in sepsis. EMBO Molecular Medicine, doi: 10.15252/emmm.202114436.
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Schmidt S, Kildgaard S, Guo HJ, Beemelmanns C, Poulsen M (2021) The chemical ecology of the fungus-farming termite symbiosis. Natural Product Reports, doi: 10.1039/d1np00022e.
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Zhang J, Ni Y, Qian L, Fang Q, Zheng T, Zhang M, Gao Q, Zhang Y, Ni J, Hou X, Bao Y, Kovatcheva Datchary P, Xu A, Li H, Panagiotou G, Jia W (2021) Decreased abundance of Akkermansia muciniphila leads to the impairment of insulin secretion and glucose homeostasis in lean type 2 diabetes. Advanced Science, doi: 10.1002/advs.202100536.
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Ni Y, Lohinai Z, Heshiki Y, Dome B, Moldavy J, Dulka E, Galffy G, Berta J, Weiss GJ, Sommer MOA, Panagiotou G (2021) Distinct composition and metabolic functions of human gut microbiota are associated with cachexia in lung cancer patients. ISME J, doi: 10.1038/s41396-021-00998-8.
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Wibowo MC, Yang Z, Borry M, Hübner A, Huang KD, Tierney BT, Zimmerman S, Barajas Olomos F, Contreras Cubas C, García Ortiz H, Martínez Hernández A, Luber JM, Kirstahler P, Blohm T, Smiley FE, Arnold R, Ballal SA, Pamp SJ, Russ J, Maixner F, Rota Stabelli O, Segata N, Reinhard K, Orozco L, Warinner C, Snow M, LeBlanc S, Kostic AD (2021) Reconstruction of ancient microbial genomes from the human gut. Nature, doi: 10.1038/s41586-021-03532-0.
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Fellows Yates JA, Velsko IM, Aron F, Posth C, Hofman CA, Austin RM, Parker CE, Mann AE, Nägele K, Arthur JW, Bauer CC, Crevecoeur I, Cupillard C, Curtis MC, Dalén L, Diáz Zorita Bonilla M, Diéz Fernández Lomana JC, Drucker DG, Escribano Escrivá E, Francken M, Gibbon VE, González Morales MR, Grande Mateu A, Harvati K, Henry AG, Humphrey L, Menéndez M, Mihailovic D, Peresani M, Rodríguez Moroder S, Roksandic M, Rougier H, Sázelová S, Stock JT, Guy Straus L, Svoboda J, Teßmann B, Walker MJ, Power RC, Lewis CM, Sankaranarayanan K, Guschanski K, Wrangham RW, Dewhirst FE, Salazar García DC, Krause J, Herbig A, Warinner C (2021) The evolution and changing ecology of the African hominid oral microbiome. PNAS, doi: 10.1073/pnas.2021655118.
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Gilaberte Basset M, Hochrainer A, Töpfer S, Riexinger F, Bickert P, León Torres JR, Steinlechner F, Gräfe M (2021) Video-Rate Imaging with Undetected Photons. Laser & Photonics Reviews, doi: 10.1002/lpor.202000327.
Wiley

 

Singh S, Thompson JA, Yilmaz B, Li H, Weis S, Sobral D, Truglio M, Aires da Silva F, Aguiar S, Carlos AR, Rebelo S, Cardoso S, Gjini E, Nuñez G, Soares MP (2021) Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis. Cell Host Microbe S1931-3128(20)30680-6.
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Last A, Maurer M, Mosig AS, Gresnigt MS, Hube B (2021) In vitro infection models to study fungal-host interactions. FEMS Microbiol Rev, doi: 10.1093/femsre/fuab005.
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Russo AJ, Vasudevan SO, Méndez Huergo SP, Kumari P, Menoret A, Duduskar S, Wang C, Pérez Sáez JM, Fettis MM, Li C, Liu R, Wanchoo A, Chandiran K, Ruan J, Kailasan Vanaja SK, Bauer M, Sponholz C, Hudalla GA, Vella AT, Zhou B, Deshmukh SD, Rabinovich GA, Rathinam VA (2021) Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin. Nature Immunology, doi: 10.1038/s41590-020-00844-7.
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