High-fat diet impairs microbial metabolite production and aggravates influenza A infection.
Hornung F, SureshKumar HK, Klement L, Reisser Y, Wernike C, Nischang V, Jordan PM, Werz O, Hoffmann C, Löffler B, Deinhardt-Emmer S 2025 High-fat diet impairs microbial metabolite production and aggravates influenza A infection. Cell Commun Signal 23, 359.
Abstract
Alterations in the gut microbiom can significantly impact various regions in the human body, including the pulmonary tract. This study investigates alterations in the gut microbiome during a high-fat diet (HFD), particularly short-chain fatty acids (SCFAs), and how these metabolites affect lung infection caused by Influenza A virus (IAV).