Bacterial Oncotraits Rather than Spatial Organization Are Associated with Dysplasia in Ulcerative Colitis.
Bruggeling C, Te Groen M, Garza D, van Heeckeren Tot Overlaer F, Krekels J, Sulaiman B, Karel D, Rulof A, Schaaphok A, Hornikx D, Nagtegaal I, Dutilh B, Hoentjen F, Boleij A 2023 Bacterial Oncotraits Rather than Spatial Organization Are Associated with Dysplasia in Ulcerative Colitis. J Crohns Colitis 17, 1870-1881.
Abstract
Colonic bacterial biofilms are frequently present in ulcerative colitis [UC] and may increase dysplasia risk through pathogens expressing oncotraits. This prospective cohort study aimed to determine [1] the association of oncotraits and longitudinal biofilm presence with dysplasia risk in UC, and [2] the relation of bacterial composition with biofilms and dysplasia risk.