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Microverse of the Environment

Microverse of the Environment lays the groundwork for experimentally determining microbial balance and dysbalance by generating synthetic microbial consortia and analyzing microbial communities from aquatic habitats. We combine our expertise in microbial culturing systems, natural product research, bio-imaging and materials science to understand the principles that govern interactions in microbial consortia. Our investigations will pave the way for rational interventions with medical and environmental implications.

Coordinators:
Axel Brakhage | Christian Hertweck | Kirsten Küsel

Publications

2022

Deng Y, Vallet M, Pohnert G (2022) Temporal and spatial signaling mediating the balance of the plankton microbiome. Ann Rev Mar Sci, doi: 10.1146/annurev-marine-042021-012353.
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2021

 

Traxler L, Shrestha J, Richter M, Krause K, Schäfer T, Kothe E (2021) Metal adaptation and transport in hyphae of the wood-rot fungus Schizophyllum commune. J Hazard Mater., doi: 10.1016/j.jhazmat.2021.127978 .
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Taubert M, Overholt WA, Heinze BM, Matanfack GA, Houhou R, Jehmlich N, von Bergen M, Rösch P, Popp J, Küsel K (2021) Bolstering fitness via CO2 fixation and organic carbon uptake: mixotrophs in modern groundwater. ISME J, doi: 10.1038/s41396-021-01163-x.
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Krespach M, Stroe MC, Flak M, Kornor AJ, Nietzsche S, Sasso S, Hertweck C, Brakhage AA (2021) Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity. PNAS, doi: 10.1073/pnas.2100892118.
pubmed - This work was funded by the CRC 1127

Venkat K, Hoyos M, Haycocks J, Cassidy L, Engelmann B, Rolle-Kampczyk U, von Bergen M, Tholey A, Grainger D, Papenfort K (2021) A dual-function RNA balances carbon uptake and central metabolism in Vibrio cholerae. EMBO J, doi: 10.15252/embj.2021108542.
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Büttner H, Niehs SP, Vandelannoote K, Cseresnyés Z, Dose B, Richter I, Gerst R, Figge MT, Stinear TP, Pidot SJ, Hertweck C (2021) Bacterial endosymbionts protect beneficial soil fungus from nematode attack. PNAS, doi: 10.1073/pnas.2110669118.
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Press AT, Babic P, Hoffmann B, Müller T, Foo W, Hauswald W, Benecke J, Beretta M, Cseresnyés Z, Hoeppener S, Nischang I, Coldewey SM, Gräler MH, Bauer R, Gonnert F, Gaßler N, Wetzker R, Figge MT, Schubert US, Bauer M (2021) Targeted delivery of a phosphoinositide 3-kinase y inhibitor to restore organ function in sepsis. EMBO Molecular Medicine, doi: 10.15252/emmm.202114436.
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Little RF, Hertweck C (2021) Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis. Natural Product Reports, doi: 10.1039/d1np00035g.
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Schmidt S, Kildgaard S, Guo HJ, Beemelmanns C, Poulsen M (2021) The chemical ecology of the fungus-farming termite symbiosis. Natural Product Reports, doi: 10.1039/d1np00022e.
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Scherlach K, Hertweck C (2021) Mining and unearthing hidden biosynthetic potential. Nature Communications, doi: 10.1038/s41467-021-24133-5.
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Yan L, Hermans S, Totsche K, Lehmann R, Herrmann M, Küsel K (2021) Groundwater bacterial communities evolve over time in response to recharge. Water Research, doi: 10.1016/j.watres.2021.117290.
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Molloy EM, Dell M, Hänsch VG, Dunbar K, Feldmann R, Oberheide A, Seyfarth L, Kumpfmüller J, Horch T, Arndt HD, Hertweck C (2021) Enzyme-primed negative chemical ligation produces autoinducing cyclopeptides in Clostridia. Angew Chem Int Ed Engl, doi: 10.1002/anie.202016378.
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Zhang S, Mukherji R, Chowdhury S, Reimer L, Stallforth P (2021) Lipopeptide-mediated bacterial interaction enables cooperative predator defense. PNAS 118(6):e2013759118.
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Schlembach I, Grünberger A, Rosenbaum MA, Regestein L (2021) Measurement Techniques to Resolve and Control Population Dynamics of Mixed-Culture Processes. Trends Biotechnol. S0167-7799(21)00012-3.
pubmed